My settings in the graphic options menu are borderless window, but you can also try fullscreen. That way I dont have the desktop problem, and when I need access to desktop, I use Alt-Tab to go there.
I am playing in windowed mod under win 10, I hit the square to have the max screen, to avoid issues with the mouse, I placed my windows bar at the top of the screen, as so if I need to google something or whatever I am just clicking on the wanted win 10 icon 
I hope that may solve your issue
I'm playing in windows mode since the beginning. Sometimes I search my mouse curser, because it's very small and I lose it then, but I have no desktop issues.
Well, I won't play fullscreen as I'm watching Netflix at the same time ! 
So I have 2 windows on my screen
It happen most of the time when I reach the bottom of RW window, just befors Win10 toolbar.
That's why I suggested to place the windows bar at the top of the screen
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